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The Role of Proteoglycans in Hair Health
Every follicle contains vital signalling molecules within the dermal papilla and inner and outer root sheath. These molecules (called Proteoglycans) help to regulate the growth of the hair and enable the follicle to perform its Hair Growth Cycle in a healthy and timely manner.
Whenever the levels of these vital molecules within the follicle are depleted, the lower concentration prevents the follicle from performing its growth cycle in a proper manner, resulting in a hair growth disruption.
This disruption can present as excess shedding, hair that won't reach its full growth potential, thinning patches and dormant follicles.
The key to restoring balance in the Hair Growth Cycle is in replenishing the levels of proteoglycans within the follicle to support follicle signalling and performance, through Proteoglycan Replacement Therapy.
What are proteoglycans?
Proteoglycans are key functional molecules, consisting of core proteins, found extensively throughout the human body and influential to the maintenance of a balanced and healthy Hair Growth Cycle and general healthy hair growth.
In the hair follicle, they are responsible for regulating the way the hair grows and are key to ensuring that each follicle performs its Hair Growth Cycle correctly. Studies have shown that, when these molecules are depleted or missing, the follicle becomes disrupted in the Hair Growth Cycle and hair thinning or hair loss occurs.
Due to the vital role that proteoglycans play in the health and function of the follicle, these studies have identified this morphology as Proteoglycan Follicular Atrophy.
What is Proteoglycan Follicular Atrophy?
Proteoglycan Follicular Atrophy is a clinically established pathology, the result of a wasting away of selective proteoglycans from the dermal papilla (the inner and outer root sheath of the follicle), coupled with an ever-decreasing ability for the body to reproduce these molecules.
Despite the many different causes and types of hair loss, Proteoglycan Follicular Atrophy is recognised as an underlying cause in almost all cases.
The hair follicles are regulated by a finely tuned dialogue between different compartments in the skin on the scalp and the hair follicles and by a delicate balance between various important growth influencers. The role of proteoglycans in hair growth control should always be considered when addressing hair growth disorders, regardless of their cause or type, as proteoglycans can effectively modulate the growth factors and the Hair Growth Cycle.
As the Hair Growth Cycle is the essential mechanism that regulates hair growth on the scalp, in order to address hair loss and restore hair growth, it is necessary to support and normalise the Hair Growth Cycle. This is most successfully achieved by replenishing the concentration of specific hair follicle proteoglycans through Proteoglycan Replacement Therapy.
Benefits of Proteoglycan Replacement Therapy
There is a well-founded scientific and clinical basis for using Proteoglycan Replacement Therapy as primary treatment for subjects suffering hair loss or hair growth disorders, regardless of the cause or type.
It has been documented that proteoglycan levels decline within the hair follicle in age-related or genetic hair loss (Androgenetic Alopecia), post-pregnancy hair loss (Postpartum Effluvium) and when experiencing stress-related hair loss (Telogen Effluvium).
Proteoglycan Replacement Therapy is rich in specific bioactive proteoglycans that are essential for the healthy function of the hair follicles and are pivotal in ensuring the follicles are consistently induced back into the Anagen phase to begin a new, revitalised Hair Growth Cycle, leading to increased hair growth, improved hair quality and ultimately, normalised healthy hair growth.
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Hair Growth+ inClinic with Marilex®-P is a bioactive proteoglycan formula used as a Proteoglycan Replacement Therapy and is specifically formulated to normalise the Hair Growth Cycle and promote normal, healthy hair growth.
Marilex®-P
Marilex®-P is the active ingredient in Hair Growth+ inClinic. Rich in the specific bioactive proteoglycans that are critical to normal healthy hair follicle cycling and hair growth. The scientifically formulated complex is an effective tried and tested Proteoglycan Replacement Therapy, helping to rebalance a disrupted Hair Growth Cycle in those who are experiencing Proteoglycan Follicular Atrophy.
Due to the nature of the Hair Growth Cycle, for best results Proteoglycan Replacement Therapy should be used for a minimum of 6 months.